Faculty Research 1990 - 1999

Title

Characterization of the mouse gene encoding phospholipid transfer protein.

Document Type

Article

Publication Date

1997

Keywords

Base-Sequence, Carrier-Proteins: ge, Cloning-Molecular, Gene-Expression-Regulation, Membrane-Proteins: ge, Mice, Molecular-Sequence-Data, Phospholipids: me, Promoter-Regions-(Genetics), SUPPORT-U-S-GOVT-P-H-S

JAX Source

Gene 1997 Mar 25;188(1):115-8

Grant

HL30086/HL/NHLBI

Abstract

The mouse gene encoding phospholipid transfer protein (PLTP) was cloned from 129/SvJ lambdaFIX(R) II library and characterized for the first time. It is comprised of 16 exons separated by 15 introns. Its gene organization strikingly resembles that encoding the human PLTP; the exon-intron junctions in these two genes are completely conserved. Sequencing analysis reveals that the putative promoter of mouse PLTP gene consists of a TATA-box, a high GC region, and several consensus sequences for the binding of transcription factors. Within the first 200 bp of the 5'-flanking region, the mouse and human PLTP genes share 81.1% identity of nt sequences and contain the consensus sequences for the transcription factors AP-2 and Sp1 at the same locations.

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