Faculty Research 1990 - 1999

Title

Mapping in the region of Danforth's short tail and the localization of tail length modifiers.

Document Type

Article

Publication Date

1997

Keywords

Animal, Chromosome-Mapping, Chromosomes-Human-Pair-1: ge, Chromosomes-Human-Pair-10: ge, Chromosomes-Human-Pair-18: ge, Chromosomes-Human-Pair-9: ge, Female, Genetic-Markers, Genome, Haplotypes, Human, Linkage-(Genetics), Male, Mice, Mice-Inbred-CBA, Mice-Mutant-Strains: ge, Polymorphism-(Genetics), Repetitive-Sequences-Nucleic-Acid, Sequence-Analysis-DNA, SUPPORT-NON-U-S-GOVT, Tail: ab

JAX Source

Genome Res 1997 Feb;7(2):108-17

Abstract

We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.

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