Faculty Research 1990 - 1999

Title

Spx1, a novel X-linked homeobox gene expressed during spermatogenesis.

Document Type

Article

Publication Date

1997

Keywords

Animal, Base-Sequence, Gene-Expression-Regulation-Developmental, Genes-Homeobox, Homeodomain-Proteins: ge, Linkage-(Genetics), Male, Mice, Molecular-Sequence-Data, Spermatogenesis: ge, SUPPORT-U-S-GOVT-P-H-S, X-Chromosome

JAX Source

Mech Dev 1997 Jul;65(1-2):87-98

Grant

ES07051/ES/NIEHS, HD29599/HD/NICHD, HD32061/HD/NICHD

Abstract

Spx1, a novel mouse homeobox gene, encodes a homeodomain characteristic of the paired-like class of homeobox genes and has been mapped to the distal end of the X chromosome. Northern blot hybridization of adult tissues detected high levels of a single Spx1 transcript in the testis. Further analysis by in situ hybridization revealed predominant Spx1 expression within the spermatogonia/preleptotene spermatocytes and round spermatids of spermatogenic stages IV-VII. These expression data suggest SPX1 may play a role in the regulation of spermatogenesis.