Faculty Research 1990 - 1999

Title

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.

Document Type

Article

Publication Date

1997

Keywords

Gene-Expression-Regulation-Enzymologic: im, Hematopoiesis: im, Immunologic-Deficiency-Syndromes: en, ge, im, Mutation: im, Protein-Tyrosine-Phosphatase: im, df, me, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Trends Biotechnol 1997 Aug;15(8):302-7

Grant

CA20408/CA/NCI, AI30046/AI/NIAID, DK36024/DK/NIDDK

Abstract

Spontaneous mouse mutations that cause severe immunodeficiency or autoimmunity are invaluable tools with which to investigate the mammalian immune system. Mutations at the 'motheaten' locus result in severe immunological dysfunction due to disruption of the structural gene encoding Src-homology 2-domain phosphatase-1 (SHP-1). This natural model for a specific protein-tyrosine-phosphatase deficiency is being widely utilized to determine the role of SHP-1 in the negative regulation of multiple signaling pathways in a number of hematopoietic lineages.

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