Faculty Research 1990 - 1999
Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.
Document Type
Article
Publication Date
1997
Keywords
Gene-Expression-Regulation-Enzymologic: im, Hematopoiesis: im, Immunologic-Deficiency-Syndromes: en, ge, im, Mutation: im, Protein-Tyrosine-Phosphatase: im, df, me, SUPPORT-U-S-GOVT-P-H-S
First Page
302
Last Page
307
JAX Source
Trends Biotechnol 1997 Aug;15(8):302-7
Grant
CA20408/CA/NCI, AI30046/AI/NIAID, DK36024/DK/NIDDK
Abstract
Spontaneous mouse mutations that cause severe immunodeficiency or autoimmunity are invaluable tools with which to investigate the mammalian immune system. Mutations at the 'motheaten' locus result in severe immunological dysfunction due to disruption of the structural gene encoding Src-homology 2-domain phosphatase-1 (SHP-1). This natural model for a specific protein-tyrosine-phosphatase deficiency is being widely utilized to determine the role of SHP-1 in the negative regulation of multiple signaling pathways in a number of hematopoietic lineages.
Recommended Citation
Shultz LD,
Rajan TV,
Greiner DL.
Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol 1997 Aug;15(8):302-7