Faculty Research 1990 - 1999

Title

Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8.

Document Type

Article

Publication Date

1997

Keywords

Base-Sequence, Chromosome-Mapping, Chromosomes-Human-Pair-4: ge, Chromosomes-Yeast-Artificial, Comparative-Study, Conserved-Sequence, Crosses-Genetic, DNA: ge, Evolution-Molecular, Female, Human, Linkage-(Genetics), Male, Mice, Mice-Inbred-C57BL, Muridae, Receptors-Neuropeptide-Y: ge, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genomics 1997 May 1;41(3):498-500

Grant

EY09193/EY/NEI, EY09580/EY/NEI, NS31348/NS/NINDS

Abstract

Npy1r and Npy2r, the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31-q32. We have now assigned Npy1r and Npy2r to conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity.

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