Faculty Research 1990 - 1999
Minor histocompatibility antigens.
Document Type
Article
Publication Date
1997
Keywords
Human, Major-Histocompatibility-Complex: im, Mice, Minor-Histocompatibility-Antigens, T-Lymphocytes: im
First Page
655
Last Page
661
JAX Source
Curr Opin Immunol 1997 Oct;9(5):655-61
Abstract
The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC counterparts, largely because minor H antigens are recognised by T cells and not by antibodies. In the past year, however, new minor H antigens have been identified at both the genetic and protein level and include Uty, a second novel gene encoding a male-specific epitope in mice, a novel autosomal gene encoding each of the H-13 alleles of mice, and a second male-specific epitope encoded by the SMCY gene.
Recommended Citation
Simpson E,
Roopenian DC.
Minor histocompatibility antigens. Curr Opin Immunol 1997 Oct;9(5):655-61