Faculty Research 1990 - 1999

Title

Minor histocompatibility antigens.

Document Type

Article

Publication Date

1997

Keywords

Human, Major-Histocompatibility-Complex: im, Mice, Minor-Histocompatibility-Antigens, T-Lymphocytes: im

JAX Source

Curr Opin Immunol 1997 Oct;9(5):655-61

Abstract

The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC counterparts, largely because minor H antigens are recognised by T cells and not by antibodies. In the past year, however, new minor H antigens have been identified at both the genetic and protein level and include Uty, a second novel gene encoding a male-specific epitope in mice, a novel autosomal gene encoding each of the H-13 alleles of mice, and a second male-specific epitope encoded by the SMCY gene.

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