Minor histocompatibility antigens.
Human, Major-Histocompatibility-Complex: im, Mice, Minor-Histocompatibility-Antigens, T-Lymphocytes: im
Curr Opin Immunol 1997 Oct;9(5):655-61
The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC counterparts, largely because minor H antigens are recognised by T cells and not by antibodies. In the past year, however, new minor H antigens have been identified at both the genetic and protein level and include Uty, a second novel gene encoding a male-specific epitope in mice, a novel autosomal gene encoding each of the H-13 alleles of mice, and a second male-specific epitope encoded by the SMCY gene.
Simpson, E and Roopenian, D C., " Minor histocompatibility antigens." (1997). Faculty Research 1990 - 1999. 993.
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