Title

Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon.

Document Type

Article

Publication Date

2004

Keywords

Antigens-Neoplasm, Antigens-Polyomavirus-Transforming, Antigens-Viral, CD8-Positive-T-Lymphocytes, Cross-Priming, Influenza-A-virus, Mice

JAX Source

Eur J Immunol 2004 Jan; 34(1):194-9.

Abstract

"Cross-priming" refers to the activation of naive CD8+ T cells by antigen-presenting cells that have acquired nominal antigens from another cell. The biological relevance of cross-priming of CD8+ T cells has recently been challenged (Zinkernagel, R. M., Eur. J. Immunol. 2002. 32: 2385-2392), on the basis that responses are weak or poorly quantitated, and the determinants recognized are undefined. Here we show that cross-priming is a robust process that elicits vigorous primary responses to multiple peptides in two well-defined systems. Our findings support the relevance of cross-priming in CD8+ T cell responses to viruses and tumor cells, and demonstrate that cross-priming elicits CD8+ T cells to determinants generated by the endogenous processing pathway.