Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K.
Document Type
Article
Publication Date
2005
Keywords
Amino-Acid-Sequence, Animals, Diabetes-Mellitus-Type-1, Female, Gene-Deletion, Incidence, Islets-of-Langerhans, Mice-Inbred-NOD, Molecular-Sequence-Data, Transgenes
First Page
619
Last Page
621
JAX Source
J Virol 2005 Jan; 79(1):619-21.
Abstract
The incidence of type 1 diabetes (T1D) is decreased in nonobese diabetic mice expressing the complete cassette of adenovirus early region 3 (E3) immunomodulating genes in pancreatic beta cells. Embedded among the antiapoptotic E3 genes is one encoding an adenovirus death protein (ADP), which contributes to release of virion particles by promoting cell lysis. Because removal of this proapoptotic protein might have further enhanced the ability of E3 proteins to prevent T1D, an ADP-inactivated E3 construct was tested. Significantly, deletion of ADP did not improve the diabetes-protective effect of an E3 gene cassette.
Recommended Citation
Pierce MA,
Svetlanov A,
Horwitz MS,
Serreze DV.
Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K. J Virol 2005 Jan; 79(1):619-21.