Title

Nonobese diabetic mice and the genetics of diabetes susceptibility.

Document Type

Article

Publication Date

2005

JAX Source

Curr Diab Rep 2005 Apr; 5(2):141-8.

Abstract

The nonobese diabetic mouse spontaneously develops an autoimmune, T-cell-mediated type 1 diabetes (T1D). Common and rare alleles both within a diabetogenic major histocompatibility complex (MHC) and multiple non-MHC genes combine to impair normal communication between the innate and acquired immune system, leading to loss of immune tolerance. An understanding of how variable collections of genes interact with each other and with environmental cues offers important insights as to the complexities of T1D inheritance in humans.

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