Title

Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.

Document Type

Article

Publication Date

2005

Keywords

Animals, Antigens-CD27, Aorta, Apolipoproteins-E, Arteriosclerosis, Case-Control-Studies, Cholesterol-Dietary, Comparative-Study, Crosses-Genetic, Female, Genetic-Predisposition-to-Disease, Membrane-Glycoproteins, Mice-Inbred-BALB-C, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Knockout, Middle-Aged, Phenotype, Polymorphism-Single-Nucleotide, Quantitative-Trait-Loci

JAX Source

Nat Genet 2005 Apr; 37(4):365-72.

Abstract

Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 (also called Ox40l or Cd134l), which encodes OX40 ligand. Here we report that mice with targeted mutations of Tnfsf4 had significantly (P

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