Development of intestinal M cells.
Immunol Rev 2005 Aug; 206(1):177-189.
Summary: Intestinal epithelium contains several specialized cell types including M cells, which can be found in the follicle-associated epithelium (FAE) or occasionally on the villi. M cells are critical for sampling of intestinal flora and for transferring pathogens across the epithelial barrier for recognition by the immune system. Development of M cells on the villi (M(v)) is independent of the presence of lymphocytes, while development of the FAE and M cells within the FAE (M(f)) is dependent on B lymphocytes. Here, the concept is discussed that B cells are not required for induction of M(f) differentiation but are required for transition to and maintenance of the mature M(f) phenotype. Signaling pathways possibly involved in the B-cell-independent stages of M-cell development are also discussed.
Mach, J; Hshieh, T; Hsieh, D; Grubbs, N; and Chervonsky, A, "Development of intestinal M cells." (2005). Faculty Research 2000 - 2009. 1095.