Title

Bioinformatics toolbox for narrowing rodent quantitative trait loci.

Document Type

Article

Publication Date

2005

Keywords

Crosses-Genetic, Databases-Genetic, Genomics, Haplotypes, Humans, Mice, Quantitative-Trait-Loci, Rats

JAX Source

Trends Genet 2005 Dec; 21(12):683-92.

Abstract

Quantitative trait locus (QTL) analysis is a powerful method for localizing disease genes, but identifying the causal gene remains difficult. Rodent models of disease facilitate QTL gene identification, and causal genes underlying rodent QTL are often associated with the corresponding human diseases. Recently developed bioinformatics methods, including comparative genomics, combined cross analysis, interval-specific and genome-wide haplotype analysis, followed by sequence and expression analysis, each facilitated by public databases, provide new tools for narrowing rodent QTLs. Here we discuss each tool, illustrate its application and generate a bioinformatics strategy for narrowing QTLs. Combining these bioinformatics tools with classical experimental methods should accelerate QTL gene identification.