Neuromuscular ataxia: a new spontaneous mutation in the mouse [In Process Citation]
Document Type
Article
Publication Date
2000
First Page
820
Last Page
823
JAX Source
Mamm Genome 2000 Oct; 11(10):820-3.
Abstract
Neuromuscular ataxia, nma, is a new autosomal recessive mutation that arose spontaneously in CBA/J inbred mice at The Jackson Laboratory. The mutation, now maintained on the B6C3FeF(1) hybrid background, when homozygous, causes small size, uncoordinated gait, dysmetria, dystonia, general weakness, and death shortly after weaning. No biochemical or morphological abnormalities have been detected. We used an intercross between the B6C3FeF(1) mutant and CAST/Ei to map the nma mutation to the proximal end of Chr 12. The most likely gene order places the mutation between D12Mit270 and D12Mit54, non-recombinant with D12Mit2 in 96 tested meioses.
Recommended Citation
Ward BP,
Wood B,
Johnson KR,
Bronson RT,
Donahue LR,
Davisson MT.
Neuromuscular ataxia: a new spontaneous mutation in the mouse [In Process Citation] Mamm Genome 2000 Oct; 11(10):820-3.