Title

The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs.

Document Type

Article

Publication Date

2000

Keywords

Female, Genes, Human, Linkage-Disequilibrium, Male, Mutagenesis, Phenotype, Quantitative-Trait, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Variation-(Genetics)

JAX Source

Nat Genet 2000 Aug; 25(4):381-4.

Grant

HL58982/HL/NHLBI, CA75056/CA/NCI, RR12305/RR/NCRR

Abstract

In model organisms, chemical mutagenesis provides a powerful alternative to natural, polygenic variation (for example, quantitative trait loci (QTLs)) for identifying functional pathways and complex disease genes. Despite recent progress in QTLs, we expect that mutagenesis is will ultimately prove more effective because the prospects of gene identification are high and every gene affecting a trait is potentially a target.

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