Title

Discovery of biological networks from diverse functional genomic data.

Document Type

Article

Publication Date

2005

Keywords

Cell-Cycle-Proteins, Computational-Biology, Computer-Graphics, Genomics, HSP90-Heat-Shock-Proteins, Molecular-Chaperones, Protein-Interaction-Mapping, Reproducibility-of-Results, Saccharomyces-cerevisiae, Saccharomyces-cerevisiae-Proteins

JAX Source

Genome Biol 2005; 6(13):R114.

Abstract

We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.