Derivation of genetic interaction networks from quantitative phenotype data.
Document Type
Article
Publication Date
2005
Keywords
Genetics, Genotype, Mutation, Phenotype, Saccharomyces-cerevisiae
JAX Source
Genome Biol 2005; 6(4):R38.
Abstract
We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways.
Recommended Citation
Drees BL,
Thorsson V,
Carter GW,
Rives AW,
Raymond MZ,
Avila CI,
Shannon P,
Galitski T.
Derivation of genetic interaction networks from quantitative phenotype data. Genome Biol 2005; 6(4):R38.