Title

Derivation of genetic interaction networks from quantitative phenotype data.

Document Type

Article

Publication Date

2005

Keywords

Genetics, Genotype, Mutation, Phenotype, Saccharomyces-cerevisiae

JAX Source

Genome Biol 2005; 6(4):R38.

Abstract

We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways.