Derivation of genetic interaction networks from quantitative phenotype data.
Genetics, Genotype, Mutation, Phenotype, Saccharomyces-cerevisiae
Genome Biol 2005; 6(4):R38.
We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways.
Drees, B L.; Thorsson, V; Carter, G W.; Rives, A W.; Raymond, M Z.; Avila, Campillo I.; Shannon, P; and Galitski, T, "Derivation of genetic interaction networks from quantitative phenotype data." (2005). Faculty Research 2000 - 2009. 1248.