Title

Gradual elimination of retroviruses in YBR/Ei mice.

Document Type

Article

Publication Date

2006

Keywords

Antibodies-Viral, DNA-Viral, Disease-Models-Animal, Disease-Susceptibility, Endogenous-Retroviruses, Immunity-Natural, Lymphoid-Tissue, Mammary-Glands-Animal, Mammary-Neoplasms-Experimental, Mammary-Tumor-Virus-Mouse, Proviruses, Retroviridae-Infections, T-Lymphocytes, Tumor-Virus-Infections, Virus-Integration

JAX Source

J Virol 2006 Mar; 80(5):2206-15.

Abstract

Mouse mammary tumor virus (MMTV), a well-characterized retrovirus that causes mammary tumors in susceptible mice, is commonly used to investigate virus-host interactions. We have shown that YBR/Ei mice demonstrate a novel, dominant mechanism of resistance to MMTV infection and MMTV-induced mammary tumors. MMTV can both establish infection in YBR/Ei mice and be transmitted by YBR/Ei mice as an infectious virus. However, virus production is severely attenuated, resulting in gradual clearance of infection in successive generations. Our transfer experiments showed that T cells generated in MMTV-infected resistant mice were required to restrict MMTV replication in susceptible mice. These results emphasize the importance of inducing T-cell responses for effective protection against retroviral infections.