Title

Multiple seizure susceptibility genes on chromosome 7 in SWXL-4 congenic mouse strains.

Document Type

Article

Publication Date

2000

Keywords

Crosses-Genetic, Genetic-Predisposition-to-Disease, Mice, Mice-Congenic, Mice-Inbred-Strains, Quantitative-Trait, Seizures, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genomics 2000 Nov; 70(1):62-5.

Grant

NS31348/NS/NINDS

Abstract

The SWXL-4 recombinant inbred mouse strain is unusually sensitive to recurrent tonic-clonic seizures upon routine handling and to seizures induced by chemoconvulsants. In a conventional intercross with the ABP/Le strain, we previously mapped a SWXL-4-derived quantitative trait locus called Szf1 (seizure frequency 1) to Chromosome 7. In the present study, we confirm the existence of Szf1 in both an independent cross and a congenic strain. However, derivative congenic recombinant strains show that an interaction between at least two genes on Chromosome 7-each of which has a very small effect on its own-account for Szf1.

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