Title

EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.

Document Type

Article

Publication Date

2006

Keywords

Antioxidants, Apoptosis, Apoptosis-Inducing-Factor, Biomechanics, Blood-Pressure, Ethylenediamines, Fibrosis, Heart-Failure-Congestive, Mice, Mitochondria, Mutation, Myocardium, Necrosis, Organometallic-Compounds, Oxidative-Stress, Reactive-Oxygen-Species, Survival-Analysis

JAX Location

see Reprint Collection

JAX Source

J Am Coll Cardiol 2006 Aug; 48(4):824-32.

Abstract

OBJECTIVES: The purpose of this study was to identify apoptosis-inducing factor (AIF) as a cardiac mitochondrial antioxidant and assess the efficacy of EUK-8, a salen-manganese catalytic free radical scavenger, to protect the AIF-deficient myocardium against pressure overload. BACKGROUND: Oxidative stress has been postulated to provoke cell death and pathologic remodeling in heart failure.

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