Title

Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse.

Document Type

Article

Publication Date

2006

Keywords

Cleft-Palate, DNA-Binding-Proteins, Embryonic-Development, Mice-Mutant-Strains, Morphogenesis, Nuclear-Matrix, Nuclear-Proteins, Palate, Phenotype, Protein-Binding, Two-Hybrid-System-Techniques

JAX Source

J Biol Chem 2006 Aug; 281(31):22352-9.

Abstract

The gene defective in fidget mice encodes fidgetin, a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. Using a yeast two-hybrid screen, we identified cAMP-dependent protein kinase A anchoring protein 95 kDa (AKAP95) as a potential fidgetin-binding protein.