Title

Developmental refinement in the mammalian thalamus.

Document Type

Article

Publication Date

2006

Keywords

Animals, Cell-Differentiation, Geniculate-Bodies, Humans, Nerve-Net, Neuronal-Plasticity, Receptors-N-Methyl-D-Aspartate, Synapses, Thalamus, Visual-Pathways

JAX Source

Crit Rev Neurobiol 2006; 18(1-2):49-59.

Abstract

The sensory relay synapses in the thalamus undergo extensive refinement during early life. Disruptions of spontaneous activity, but not sensory deprivation, can induce large-scale re-organization of neuronal connections in the thalamus. Recent studies also reveal an extended period of synaptic refinement in the visual and somatosensory relay synapses, where sensory deprivation produces some unexpected effects on synaptic remodeling. This article aims to provide a brief overview of recent findings and current ideas about the refinement of relay synapses in the thalamus.

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