Title

Humanized mice in translational biomedical research.

Document Type

Article

Publication Date

2007

Keywords

Chimera, Communicable-Diseases, Disease-Models-Animal, Hematopoiesis, Humans, Mice-Knockout, Mice-SCID, Mice-Transgenic, Neoplasms

JAX Source

Nat Rev Immunol 2007 Feb; 7(2):118-30.

Abstract

The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.