Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice.
Document Type
Article
Publication Date
2007
Keywords
Behavior-Animal, Calcium-Binding-Proteins, Cochlear-Diseases, Ear-Inner, Eye-Diseases, Heterozygote, Intercellular-Signaling-Peptides-and-Proteins, Membrane-Proteins, Mice-Inbred-C57BL, Phenotype
First Page
307
Last Page
311
JAX Source
Genetics 2007 Sep; 177(1):307-11.
Abstract
Mice heterozygous for missense mutations of the Notch ligand Jagged1 (Jag1) exhibit head-shaking behavior indicative of an inner ear vestibular defect. In contrast, mice heterozygous for a targeted deletion of the Jag1 gene (Jag1del1) do not demonstrate obvious head-shaking behavior. To determine whether the differences in inner ear phenotypes were due to the types of Jag1 mutations or to differences in genetic background, we crossed Jag1del1 heterozygous mice onto the same genetic background as the missense mutants. This analysis revealed that variation of the Jag1 mutant inner ear phenotype is caused by genetic background differences and is not due to the type of Jag1 mutation. Genome scans of N2 backcross mice identified a significant modifier locus on chromosome 7, as well as a suggestive locus on chromosome 14. We also analyzed modifiers of an eye defect in Jag1del1 heterozygous mice from this same cross.
Recommended Citation
Kiernan AE,
Li R,
Hawes NL,
Churchill GA,
Gridley T.
Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice. Genetics 2007 Sep; 177(1):307-11.