Title

Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous in transgenic line TgN3261Rpw.

Document Type

Article

Publication Date

2000

Keywords

Blotting-Southern, Dog-Diseases, Dogs, Eye-Abnormalities, Hyperplasia, Lens-Crystalline, Mice, Mice-Mutant-Strains, Mice-Transgenic, Mutagenesis-Insertional, Vitreous-Body

JAX Source

Vet Pathol 2000 Sep; 37(5):422-7.

Abstract

Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous are congenital ocular anomalies that can lead to cataract formation. A line of insertional mutant mice, TgN3261Rpw, generated at the Oak Ridge National Laboratory in a large-scale insertional mutagenesis program was found to have a low incidence (8/243; 3.29%) of multiple developmental ocular abnormalities. The ocular abnormalities include persistent hyperplastic primary vitreous, persistent hyperplastic tunica vasculosa lentis, failure of cleavage of the anterior segment, retrolental fibrovascular membrane, posterior polar cataract, and detached retina. This transgenic mouse line provides an ontogenetic model because of the high degree of similarity of this entity in humans, dogs, and mice.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS