Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous in transgenic line TgN3261Rpw.
Document Type
Article
Publication Date
2000
Keywords
Blotting-Southern, Dog-Diseases, Dogs, Eye-Abnormalities, Hyperplasia, Lens-Crystalline, Mice, Mice-Mutant-Strains, Mice-Transgenic, Mutagenesis-Insertional, Vitreous-Body
First Page
422
Last Page
427
JAX Source
Vet Pathol 2000 Sep; 37(5):422-7.
Abstract
Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous are congenital ocular anomalies that can lead to cataract formation. A line of insertional mutant mice, TgN3261Rpw, generated at the Oak Ridge National Laboratory in a large-scale insertional mutagenesis program was found to have a low incidence (8/243; 3.29%) of multiple developmental ocular abnormalities. The ocular abnormalities include persistent hyperplastic primary vitreous, persistent hyperplastic tunica vasculosa lentis, failure of cleavage of the anterior segment, retrolental fibrovascular membrane, posterior polar cataract, and detached retina. This transgenic mouse line provides an ontogenetic model because of the high degree of similarity of this entity in humans, dogs, and mice.
Recommended Citation
Colitz CM,
Malarkey DE,
Woychik RP,
Wilkinson JE.
Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous in transgenic line TgN3261Rpw. Vet Pathol 2000 Sep; 37(5):422-7.