Title

A revised nomenclature for the human and rodent alpha-tubulin gene family.

Document Type

Article

Publication Date

2007

Keywords

DNA-Complementary, Humans, Mice, Multigene-Family, Phylogeny, Rats, Terminology-as-Topic, Tubulin

JAX Source

Genomics 2007 Aug; 90(2):285-9.

Abstract

An essential component of microtubules, alpha-tubulin is also a multigene family in many species. An orthology-based nomenclature for this gene family has previously been difficult to assign due to incomplete genome builds and the high degree of sequence similarity between members of this family. Using the current genome builds, sequence analysis of human, mouse, and rat alpha-tubulin genes has enabled an updated nomenclature to be generated. This revised nomenclature provides a unified language for the discussion of these genes in mammalian species; it has been approved by the gene nomenclature committees of the three species and is supported by researchers in the field.