Title

Mouse models for understanding the growth hormone insulin-like growth factor-I axis.

Authors

C J. Rosen

Document Type

Article

Publication Date

2007

JAX Location

see Reprint Collection ( a pdf is available)

JAX Source

Horm Res 2007; 68(Suppl 5):2-4.

Abstract

BACKGROUND: Mouse models that include spontaneous mutations, as well as those carrying allelic differences, have been extremely useful in clarifying the role of skeletal and circulating insulin-like growth factor I (IGF-I) in peak bone acquisition. The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the relationship of marrow fat to skeletal mass. CONCLUSIONS: Mouse models continue to deepen our understanding of IGF-I signaling and the role of IGF-I in determining marrow stromal cell fate.

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