Title

Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14.

Document Type

Article

Publication Date

2008

Keywords

Cataract, Human-papillomavirus-18, Humans, Immunohistochemistry, Keratin-14, Mice-Transgenic, Oncogene-Proteins-Viral, Promoter-Regions-(Genetics), Transgenes

JAX Location

see Reprint Collection (a pdf is available)

JAX Source

Exp Mol Pathol 2008 Oct; 85(2):77-82.

Abstract

Human papillomavirus type 18 (HPV18) is a common cause of cervical cancer. To create a mouse model for this common neoplastic disease, we used a human keratin 14 promoter to drive the HPV18 E7 oncogene to create transgenic mice. No mice up to a year of age developed cervical cancer. However, all transgenic mice and none of the controls developed progressive bilateral cortical cataracts. By 6 months of age, the cortex liquefied leaving the lens nucleus. Proliferation of lens epithelium formed multifocal nodules and free floating lens epithelial cells within the liquefied cortex. These cells were hyperplastic not neoplastic. Other HPV transgenic stocks develop cataracts suggesting this virus may have a broad cellular tropism.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS