Identification of quantitative trait loci for locomotor activation and anxiety using closely-related inbred strains.
Document Type
Article
Publication Date
2008
First Page
761
Last Page
769
JAX Location
see Reprint Collection.
JAX Source
Genes Brain Behav 2008; 7:761-769.
Abstract
We carried out a QTL mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ENU-mutagenesis mapping study. Surprisingly, although open field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on chromosome 8 having associations with multiple open field measures and a significant interaction between loci on chromosomes 13 and 17. Together, the chromosome 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on chromosomes 1 and 6 present in a subset of the behaviors.
Recommended Citation
Bailey JS,
Grabowski BL,
Steffy BM,
Wiltshire T,
Churchill GA,
Tarantino LM.
Identification of quantitative trait loci for locomotor activation and anxiety using closely-related inbred strains. Genes Brain Behav 2008; 7:761-769.