Protection from clinical peripheral sensory neuropathy in Alstrom syndrome in contrast to early-onset type 2 diabetes.
Document Type
Article
Publication Date
2009
Keywords
Adult, Blindness, Child, Diabetes-Mellitus-Type-2, Foot-Ulcer, Genetic-Diseases-Inborn, Humans, Peripheral-Nervous-System-Diseases, Syndrome, Young-Adult
First Page
462
Last Page
464
JAX Source
Diabetes Care 2009 Mar; 32(3):462-4.
Abstract
OBJECTIVE: Alstrom syndrome, with type 2 diabetes, and blindness could confer a high risk of foot ulceration. Clinical testing for neuropathy in Alstrom syndrome and matched young-onset type 2 diabetic subjects was therefore undertaken. RESEARCH DESIGN AND METHODS: Fifty-eight subjects with Alstrom syndrome (18 insulin-resistant nondiabetic and 40 diabetic; aged 8-43 years) and 30 young-onset diabetic subjects (aged 13-35 years) were studied. Neuropathy symptom questionnaires were administered. Graded monofilament and 128-MHz tuning fork vibration perception were assessed in both feet. RESULTS: Neuropathic symptoms, loss of monofilament, and/or vibration perception were reported by 12 of the 30 young-onset type 2 diabetic subjects (6 had neuropathic ulceration) but none of the subjects with Alstrom syndrome. CONCLUSIONS: The striking preservation of protective foot sensation in Alstrom syndrome may provide a clue to the causes of differential susceptibility to neuropathy in the wider diabetic population.
Recommended Citation
Paisey RB,
Paisey RM,
Thomson MP,
Bower L,
Maffei P,
Shield JP,
Barnett S,
Marshall JD.
Protection from clinical peripheral sensory neuropathy in Alstrom syndrome in contrast to early-onset type 2 diabetes. Diabetes Care 2009 Mar; 32(3):462-4.