Title

Combined histologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice.

Document Type

Article

Publication Date

2001

Keywords

Crosses-Genetic, Disease-Models-Animal, Female, Gene-Rearrangement, Gene-Rearrangement-beta-Chain-T-Cell-Antigen-Receptor, Genes-T-Cell-Receptor-beta, Immunoglobulins-Heavy-Chain, Immunoglobulins-kappa-Chain, Lymphoma-Large-Cell, Lymphoma-Lymphoblastic, Lymphoma-Non-Hodgkin, Mice-Inbred-AKR, Mice-Inbred-DBA, Mice-Knockout

JAX Location

see Reprint Collection.

JAX Source

Leuk Res 2001 Aug; 25(8):719-33

Grant

CA33093/CA/NCI

Abstract

Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V(+) and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements.

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