Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice.
Document Type
Article
Publication Date
2001
Keywords
Animal, Aorta, Arteriosclerosis, Chromosome-Mapping, Crosses-Genetic, Crossing-Over-(Genetics), DNA, DNA-Primers, Diet-Atherogenic, Female, Genetic-Markers, Genetic-Predisposition-to-Disease, Linkage-(Genetics), Male, Mice, Mice-Inbred-C57BL, Polymerase-Chain-Reaction, Quantitative-Trait, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S
First Page
495
Last Page
500
JAX Source
Mamm Genome 2001 Jul; 12(7):495-500.
Grant
HL32087/HL/NHLBI
Abstract
Ath6 is a novel quantitative trait locus associated with differences in susceptibility to atherosclerosis between C57BL/6J (B6) and C57BLKS/J (BKS) inbred mouse strains. Combining data from an intercross and a backcross (1593 meioses) between mice from B6 and BKS strains and from The Jackson Laboratory interspecific backcross panels, (C57BL/6J x Mus spretus) F1 x C57BL/6J and (C57BL/6J x SPRET/Ei) F1 x SPRET/Ei, we constructed a consensus genetic map and narrowed Ath6 to a 1.07 +/- 0.26 cM interval between the anonymous DNA marker D12Pgn4 and the gene Nmyc1. This region is near the proximal end of murine Chromosome (Chr) 12, which is homologous to the human chromosomal region 2p24-p25. Marker order in the Ath6 region was concordant among the two crosses and The Jackson Laboratory interspecific backcross panels. This high resolution map rules out candidate genes encoding apolipoprotein B, syndecan 1, and Adam17. The two Ath6 crosses have a combined potential resolution of 0.06 cM.
Recommended Citation
Purcell MK,
Mu JL,
Higgins DC,
Elango R,
Whitmore H,
Harris S,
Paigen B.
Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice. Mamm Genome 2001 Jul; 12(7):495-500.