Title

Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases.

Document Type

Article

Publication Date

2000

Keywords

Animal, Blotting-Northern, Cell-Movement, Chromosome-Mapping, Cloning-Molecular, Crosses-Genetic, Germ-Cells, Human, Insect-Proteins, Mice, Mice-Inbred-C57BL, Molecular-Sequence-Data, Phosphatidate-Phosphatase, Polymerase-Chain-Reaction, Sequence-Alignment, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genomics 2000 Jan; 63(1):142-4.

Grant

RO1NS36437/NS/NINDS, RO1HD34883/HD/NICHD, CA34196/CA/NCI

Abstract

The wunen gene of Drosophila melanogaster encodes a multipass membrane-spanning protein that negatively regulates primordial germ cell migration. Here we describe the cloning of a mouse gene that encodes a protein homologous to wunen and to the Type 2 phosphatidic acid phosphatases. This gene encodes a 251-amino-acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c. Northern blot analysis revealed the presence of a single 1.9-kb Ppap2c transcript. The Ppap2c gene was localized to the central portion of mouse Chromosome 10 by interspecific backcross analysis. Copyright 2000 Academic Press.

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