Title

International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.

Document Type

Article

Publication Date

2002

Keywords

Autoantibodies, Autoantigens, Diabetes-Mellitus-Insulin-Dependent, Disease-Models-Animal, Glutamate-Decarboxylase, Human, Insulin, Mice, Mice-Inbred-NOD

JAX Location

see Reprint Collection

JAX Source

Ann N Y Acad Sci 2002 Apr; 958:1-2.

Abstract

The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in the NOD mouse model for type 1 diabetes. It was demonstrated that insulin autoantibodies measured by sensitive radiobinding assay are a marker of autoimmunity in NOD mice and draw into question the true nature of GADA and IA-2A in this animal model.

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