Subversion of the innate immune system by a retrovirus.
Document Type
Article
Publication Date
2003
Keywords
Interleukin-10, Mammary-Tumor-Virus-Mouse, Membrane-Glycoproteins, Mice, Mice-Inbred-C3H", Mice-Inbred-C57BL", Receptors-Cell-Surface, Recombinant-Proteins, Retroviridae-Infections, Selection-(Genetics), Signal-Transduction, Support-Non-U, S, -Gov't", Support-U, S, -Gov't-P, H, S, ", Tumor-Virus-Infections
First Page
573
Last Page
578
JAX Source
Nat Immunol 2003 Jun; 4(6):573-8.
Abstract
Retroviruses evolve rapidly to avoid the immune response of the infected host. We show here that the wild-type mouse mammary tumor virus MMTV(C3H) persisted indefinitely in C3H/HeN mice. However, it was rapidly lost in" mice of the closely related C3H/HeJ strain and was replaced by a virus recombinant with an endogenous Mtv provirus. Maintenance of the wild-type virus was dependent on Toll-like receptor-4 (TLR4) signaling, which" triggered production of the immunosuppressive cytokine interleukin-10. In the presence of mutant TLR4 in C3H/HeJ mice, wild-type virus was" eliminated by the cytotoxic immune response, promoting selection of the" immune escape recombinant MMTV variants. Thus, subversion of the innate" immune system is yet another survival strategy used by retroviruses.
Recommended Citation
Jude BA,
Pobezinskaya Y,
Bishop J,
Parke S,
Medzhitov RM,
Chervonsky AV,
Golovkina TV.
Subversion of the innate immune system by a retrovirus. Nat Immunol 2003 Jun; 4(6):573-8.