TCF and Groucho-related genes influence pituitary growth and development.
Document Type
Article
Publication Date
2003
First Page
2152
Last Page
2161
JAX Location
see Journal Stacks
JAX Source
Mol Endocrinol 2003 Nov; 17(11):2152-61.
Abstract
Mutations in the prophet of PIT1 gene (PROP1) are the most common cause of multiple pituitary hormone deficiency in humans; however, the mechanism of PROP1 action is not well understood. We report that Prop1 is essential for dorsally restricted expression of a Groucho-related gene, transducin-like enhancer of split 3 (Tle3), which encodes a transcriptional corepressor. Deficiency of a related gene, amino terminal enhancer of split (Aes), causes pituitary anomalies and growth insufficiency. TLE3 and AES have been shown to interact with TCF/LEF (transcripiton factors of the T cell-specific and lymphoid enhancer specific group) family members in cell culture systems. In the absence of TCF4 (Tcf7L2), Prop1 levels are elevated, pituitary hyperplasia ensues and palate closure is abnormal. Thus, we demonstrate that Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1.
Recommended Citation
Brinkmeier ML,
Potok MA,
Cha KB,
Gridley T,
Stifani S,
Meeldijk J,
Clevers H,
Camper SA.
TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol 2003 Nov; 17(11):2152-61.