Title

Acoustic startle and prepulse inhibition in 40 inbred strains of mice.

Document Type

Article

Publication Date

2003

Keywords

Animal, Comparative-Study, Female, Male, Mice, Mice-Inbred-Strains, Phenotype, Reference-Values, Startle-Reaction

JAX Location

see Reprint Collection

JAX Source

Behav Neurosci 2003 Aug; 117(4):716-27.

Abstract

A high-throughput phenotype screening protocol was used to measure the acoustic startle response (ASR) and prepulse inhibition (PPI) in mice. ASRs were evoked by noise bursts; prepulses for PPI were 70 dB sound pressure level tones of 4, 12, and 20 kHz. Forty inbred strains of mice were tested (in most cases using 10 males and 10 females of each strain). The data on both the ASR and PPI had high internal and test-retest reliability and showed large differences among inbred strains, indicative of strong genetic influences. Previously obtained measures of hearing sensitivity in the same inbred strains were not significantly correlated with ASR or PPI measures.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS