Title

Tracking autoimmune T cells in diabetes.

Document Type

Article

Publication Date

2003

Keywords

Autoimmunity, CD4-Positive-T-Lymphocytes, Diabetes-Mellitus-Insulin-Dependent, Human, Islets-of-Langerhans, Major-Histocompatibility-Complex, Mice, Mice-Inbred-NOD, Models-Molecular, Molecular-Mimicry, Peptide-Library, Peptides

JAX Source

J Clin Invest 2003 Sep; 112(6):826-8.

Abstract

Insulin-dependent diabetes mellitus is usually caused by the autoimmune destruction of pancreatic beta cells by T cells. Methodologies to track the development, migration, and functional activation of one class of such T cells (CD4 T cells) have been limited. However, it now appears that this limitation has been overcome.