Title

Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome.

Document Type

Article

Publication Date

2003

JAX Location

see Journal stacks

JAX Source

Biotechniques 2003 Dec; 35(6):1170-4, 1176, 1178.

Abstract

The Ts65Dn mouse is a segmentally trisomic model for Down syndrome. Until now, Ts65Dn mice have been identified by the laborious methods of either chromosomal analysis of cultured peripheral lymphocytes or fluorescent in situ hybridization (FISH). We report here a quantitative PCR method for genotyping Ts65Dn mice, as well as a phenotypic description for visually preclassifying mice to be genotyped.

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