Title

Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.

Document Type

Article

Publication Date

2000

Keywords

Brugia-malayi, Disease-Models-Animal, Elephantiasis-Filarial, Human, Interferon-Type-II, Interleukin-4, Mice, Mice-Inbred-BALB-C, Mice-Inbred-C57BL, Mice-SCID, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Infect Immun 2000 May; 68(5):3034-5.

Grant

AI39705/AI/NIAID, AI42362/AI/NIAID, AI30389/AI/NIAID

Abstract

We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.