Animal and in vitro models for the study of hair follicles.
Document Type
Article
Publication Date
2003
Keywords
Cells-Cultured, Hair, Hair-Follicle, Human, Mice, Mice-Mutant-Strains, Organ-Culture
First Page
39
Last Page
45
JAX Source
J Investig Dermatol Symp Proc 2003; 8(1):39-45.
Abstract
Since the way in which the hair follicle functions is not well understood, many hair disorders are poorly controlled. A range of in vitro and in vivo models have therefore been developed to investigate the cell biological and biochemical mechanisms involved in the organization of this complex tissue. These range from cultures of a single cell type, such as those of the regulatory, mesenchyme-derived dermal papilla, through organ culture of isolated follicles to natural or genetically manipulated animal models. Each system has advantages and disadvantages for studying particular aspects of follicular function and some are potentially useful for the development of novel treatments for hair disorders.
Recommended Citation
Randall VA,
Sundberg JP,
Philpott MP.
Animal and in vitro models for the study of hair follicles. J Investig Dermatol Symp Proc 2003; 8(1):39-45.