Title

Glioma models.

Document Type

Article

Publication Date

2001

Keywords

Astrocytoma, Brain-Neoplasms, Cell-Cycle, Cell-Differentiation, Disease-Models-Animal, Glioblastoma, Glioma, Humans, Models-Genetic, Oligodendroglioma, Signal-Transduction

JAX Source

Biochim Biophys Acta 2001 Aug; 1551(1):M19-27.

Abstract

Gliomas are primary central nervous system tumors that arise from astrocytes, oligodendrocytes or their precursors. Gliomas can be classified into several groups according to their histologic characteristics, the most malignant of the gliomas is glioblastoma multiforme. In contrast to the long-standing and well-defined histopathology, the underlying molecular and genetic bases for gliomas are only just emerging. Many genetic alterations have been identified in human gliomas, however, establishing unequivocal correlation between these genetic alterations and gliomagenesis requires accurate animal models for this disease. Here we are reviewing the existing animal models for gliomas with different strategies and our current knowledge on the important issues about this disease, such as activation of signal transduction pathways, disruption of cell cycle arrest pathways, cell-of-origin of gliomas, and therapeutic strategies.