Title

Quantitative trait loci and candidate genes regulating HDL cholesterol: a murine chromosome map.

Document Type

Article

Publication Date

2002

Keywords

Cholesterol-HDL, Chromosome-Mapping, Genes-Regulator, Genetic-Markers, Humans, Mice, Quantitative-Trait-Heritable

JAX Source

Arterioscler Thromb Vasc Biol 2002 Sep; 22(9):1390-401.

Abstract

OBJECTIVE: Summarizing the many discovered mouse and human quantitative trait loci (QTL) for high density lipoprotein (HDL) cholesterol (HDL-C) levels is important for guiding future research on the genetic regulation of HDL concentrations and for finding gene targets for upregulating HDL levels in mice and humans. METHODS AND RESULTS: We summarized the 27 QTL and candidate genes associated with HDL-C concentrations in mice and plotted them on a mouse chromosome map. We also summarized the 22 human QTL for HDL-C levels and compared them with those of the mouse by comparative genomics. At least part of the mouse homologies for 18 of the 22 human HDL-C QTL were within the murine HDL-C QTL. CONCLUSIONS: Murine QTL for HDL-C levels may predict their homologous location in humans, and their underlying genes may be appropriate genes to test in humans.