Title

Cell movements during gastrulation: snail dependent and independent pathways.

Document Type

Article

Publication Date

2002

Keywords

Caenorhabditis-elegans, Cell-Division, Cell-Movement, DNA-Binding-Proteins, Drosophila, Drosophila-Proteins, Gastrula, Gene-Expression-Regulation-Developmental, Mice, Proto-Oncogene-Proteins, Receptors-Cell-Surface, Signal-Transduction, Toll-Like-Receptors, Transcription-Factors, Wnt-Proteins, Zebrafish-Proteins

Abstract

The morphogenetic process of gastrulation requires multiple inputs and intricate coordination. Genetic analyses demonstrate critical roles of vertebrate and invertebrate Snail proteins in this process. Together with other regulatory molecules including Wnt and BMP, the Snail pathways specify cell fate and reorganize cellular machineries to coordinate morphological changes and cell movements during gastrulation.

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