Title

Calorie restriction modulates age-dependent changes in the retinas of brown norway rats [In Process Citation]

Document Type

Article

Publication Date

2000

JAX Source

Mech Ageing Dev 2000 Mar; 114(2):133-47.

Abstract

The present study examined the effect of a 40% reduction in caloric intake (CR) versus ad libitum (AL) feeding on retinal aging. CR- and AL-fed Brown Norway (BN) rats were obtained at 12, 24 and 30 months of age from the National Center for Toxicological Research (NCTR). Age-dependent declines in outer nuclear layer (ONL=photoreceptor) cell densities, ONL height, inner nuclear layer (INL) cell densities, and thicknesses of the inner retina and whole retina were quantified in thick sections at six loci across the circumference of the sensory retina (four peripheral, two central). Data were analyzed by repeated measures, general linear models. Aging in both diet groups was associated with declines in ONL cell density, ONL height, peripheral INL cell density and total retinal thickness (P

Please contact the Joan Staats Library for information regarding this document.

Share

COinS