Title

Astrocyte differentiation states and glioma formation.

Document Type

Article

Publication Date

2003

Keywords

Astrocytoma, Cell-Cycle, Cell-Transformation-Neoplastic, Glioma, Humans, Mice, Models-Animal, Neuroglia, Receptor-Protein-Tyrosine-Kinases, Signal-Transduction

JAX Location

see Reprint Collection

JAX Source

Cancer J 2003 Mar-Apr; 9(2):72-81.

Abstract

Gliomas are the most common primary malignancy in human central nervous system. Many similarities in cell morphology and expression of markers exist between cancerous cells and normal undifferentiated progenitor cells. At the molecular level, many important gene products are causally implicated in both the glial differentiation process and glial neoplasm formation. These observations raise the question of to what degree cell differentiation state influences glioma formation. In this review, we discuss new insights into the parallels between glial differentiation and glioma formation as well as the potential application of differentiation-inducing therapy.

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