Title

Kick it up a Notch: NOTCH1 activation in T-ALL.

Authors

T GridleyFollow

Document Type

Article

Publication Date

2004

Keywords

Humans, Leukemia-T-Cell-Acute, Mutation, Receptors-Cell-Surface, Signal-Transduction, Transcription-Factors

JAX Source

Cancer Cell 2004 Nov; 6(5):431-2.

Abstract

While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. A recent paper by Weng et al. (2004) demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL.

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