Title

Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice.

Document Type

Article

Publication Date

2010

Keywords

Antibodies, Antigens-CD4, Contrast-Media, Gold, Lymph-Nodes, Mice, Nanoparticles, Tomography-X-Ray-Computed

JAX Location

see Reprint collection, a pdf is available

JAX Source

Nano Lett 2010 Jul; 10(7):2318-22.

Abstract

Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent.

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