Transcriptional programs controlling perinatal lung maturation.
PLoS One 2012; 7(8):e37046.
The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In this study, we designed a genome-wide mRNA expression time-course study from E15.5 to Postnatal Day 0 (PN0) using lung RNAs from C57BL/6J (B6) and A/J mice that differ in gestational length by ∼30 hr (B6
Xu, Yan; Wang, Yanhua; Besnard, Valérie; Ikegami, Machiko; Wert, Susan E; Heffner, Caleb; Murray, Stephen A; Donahue, Leah Rae; and Whitsett, Jeffrey A, "Transcriptional programs controlling perinatal lung maturation." (2012). Faculty Research 2012. 149.