Transcriptional programs controlling perinatal lung maturation.
Document Type
Article
Publication Date
1-1-2012
JAX Source
PLoS One 2012; 7(8):e37046.
PMID
22916088
Volume
7
Issue
8
First Page
37046
Last Page
37046
ISSN
1932-6203
Abstract
The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In this study, we designed a genome-wide mRNA expression time-course study from E15.5 to Postnatal Day 0 (PN0) using lung RNAs from C57BL/6J (B6) and A/J mice that differ in gestational length by ∼30 hr (B6
Recommended Citation
Xu Y,
Wang Y,
Besnard V,
Ikegami M,
Wert S,
Heffner C,
Murray S,
Donahue L,
Whitsett J.
Transcriptional programs controlling perinatal lung maturation. PLoS One 2012; 7(8):e37046.