Title

Contact is repulsive, but please note the "enclosed".

Document Type

Article

Publication Date

1-17-2012

JAX Source

Dev Cell 2012 Jan 17; 22(1):5-6.

Abstract

Previous models of neuronal dendrite arborization suggested that contact-dependent self-avoidance between dendrite branches prevents self-crossings within the arbor. Two papers in Neuron show how integrin-mediated adhesion to the extracellular matrix restricts dendrites to a two-dimensional space to optimize this mechanism (Han et al., 2012; Kim et al., 2012).